Sirturo

Read the medication guide provided by your pharmacist before you start taking bedaquiline and each time you get a refill.

Sirturo. Sirturo is the first anti tb drug to interfere with bacterial energy metabolism. Sirturo bedaquiline is a great addition to tuberculosis regimens but only if your tuberculosis can t be treated with all of the typical tuberculosis drugs. Sirturo is the first anti tb drug to interfere with bacterial energy metabolism. You must take it with at least 3 other medications.

Sirturo specifically inhibits mycobacterial atp adenosine 5 triphosphate synthase by binding to subunit c of the enzyme that is essential for the generation of energy in. Furthermore sirturo was the first of a new class of medicines for which cross resistance had not yet occurred. Sirturo adds a novel mechanism of action to the treatment of pulmonary mdr tb. Warnings and precautions increased mortality.

Serious side effects include qt prolongation liver dysfunction and an. Sirturo bedaquiline should not be taken alone to treat your tuberculosis. Discontinue sirturo if significant ventricular arrhythmia or if qtcf interval prolongation of greater than 500 ms develops. Sirturo is the first medication for pulmonary mdr tb with a novel mechanism of action in over 40 years mechanism of action.

Sirturo is a tuberculosis medicine that contains the active substance bedaquiline. Tuberculosis is an infection caused by the bacterium mycobacterium tuberculosis. About sirturo sirturo bedaquiline is a first in class atp synthase inhibitor for pulmonary multi drug resistant tb mdr tb. 5 7 it is mechanistically and structurally unrelated to current first line agents.

Sirturo is used in combination with other tuberculosis medicines in adults and adolescents aged 12 years and older and weighing at least 30 kg with tuberculosis in the lung that is multi drug resistant resistant to at least. Sirturo bedaquiline is an antibiotic that fights bacteria sirturo is used together with other medications to treat tuberculosis of the lungs that has been resistant to other antibacterial medications. If you have any questions ask your doctor or. Sirturo is for use in adults and children at least 12 years old and weighing at least 66 pounds 30 kilograms.

Specifically it is used to treat multi drug resistant tuberculosis mdr tb along with other medications for tuberculosis. Cross resistance is when bacteria resistant to one medicine are also resistant to a different medicine not used previously which is often the case with multi drug resistant tuberculosis. Bedaquiline sold under the brand name sirturo is a medication used to treat active tuberculosis. Sirturo is a diarylquinoline antimycobacterial drug indicated as part of combination therapy in the treatment of adult and pediatric patients 5 years and older and weighing at least 15 kg with pulmonary multi drug resistant tuberculosis mdr tb.

Common side effects include nausea joint pains headaches and chest pain.